See Creating a backup job by using the Backup Wizard.
The Command Line Applet can be used with Backup Exec when Backup Exec is installed in a cluster. The only limitation is that you cannot use the Command Line Applet to specify a device for backup. You can use the Command Line Applet to target a device pool, but not a specific device in that pool.
More Information
Backing up local disks in a Veritas cluster
Backing up shared disks in a Veritas cluster
Backing up database files in a Veritas cluster
About backing up Windows 2000 and Windows Server 2003/2008 features in a Veritas cluster