To protect all data in the cluster, which includes file shares, databases, and the cluster quorum, back up the following:
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Local disks, Shadow Copy Components, and System State on each node. The cluster quorum, which contains recovery information for the cluster and information about changes to the cluster configuration, is included in the System State backup.
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All shared disks, including the data in the Microsoft Cluster Server folder on the Quorum disk.
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Virtual servers, which may contain data or contain applications such as Microsoft SQL Server or Exchange Server. Use Backup Exec database agents to back up databases.
The Command Line Applet can be used with Backup Exec when Backup Exec is installed in a cluster. The only limitation is that you cannot use the Command Line Applet to specify a device for backup. You can use the Command Line Applet to target a device pool, but not a specific device in that pool.
More Information
Backing up local disks in a Microsoft cluster
Backing up shared disks in a Microsoft cluster
Backing up database files in a Microsoft cluster
About backing up Windows 2000 and Windows Server 2003/2008 features in a Veritas cluster